Plain-English translation of NCT06470022 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether the Medtronic Evolut FX valve works as well as the Edwards Sapien 3 Ultra Resilia valve for treating aortic stenosis — a condition where your heart's aortic valve narrows and doesn't open properly. Both are replacement valves placed through a small tube in your groin (rather than open-heart surgery). The study will track how well each valve performs over time and whether patients have similar outcomes with either one.
Aortic stenosis is a serious heart condition, and patients need safe, effective valve replacements. While both of these valves are used in clinical practice, doctors want to know whether one performs better than the other in the long term, so they can give patients the best choice.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to receive one of the two heart valve replacements during a minimally invasive procedure performed through a small tube inserted in your groin. After your procedure, you will be followed by your medical team with imaging tests (like heart scans) and possibly some stress tests to monitor how well the valve is working. The study will track your health and valve performance over the long term to compare outcomes between the two valve types.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
Denmark
Christian Juhl Terkelsen
Collaborators
Department of Clinical Epidemiology, Aarhus University, DK-8200 Aarhus N, Denmark
Enrollment target
~1,346 participants
Started
August 2024
Primary completion
July 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Christian J Terkelsen, Professor
Department of cardiology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.