Plain-English translation of NCT06470295 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This research study is testing whether a substance called can help your body fight back against dangerously low blood sugar. Researchers will safely lower your blood sugar using insulin, then see whether helps your body produce glucose more quickly to bring your blood sugar back up. The study involves both people with type 1 diabetes and people without diabetes, so researchers can understand how this treatment works in both groups.
Low blood sugar is one of the biggest challenges for people managing type 1 diabetes — it's dangerous and scary, and it makes people afraid to use insulin as prescribed. Animal studies suggest that this treatment might help the body's natural defense systems kick in faster during low blood sugar, which could make diabetes management safer and easier.
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You will visit the clinic twice. During each visit, researchers will use IV lines to slowly lower your blood sugar by infusing insulin, then give you either the treatment or a placebo (salt water) while monitoring your blood sugar and hormone levels. The two visits allow researchers to compare how your body responds with and without the treatment. If you have type 1 diabetes, you'll also wear a glucose monitor for 10 days before your visit so researchers can make sure your blood sugar is stable going in.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
United States