Plain-English translation of NCT06475105 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether acetazolamide — a water pill taken by mouth — works better when combined with an intravenous water pill (furosemide) to treat acute decompensated heart failure. People with this condition have fluid buildup in their bodies that needs to be removed. Researchers think that combining these two medications might help patients get better faster and need smaller total doses of water pills.
When the heart becomes too weak to pump effectively, fluid builds up in the lungs, legs, and abdomen, causing serious symptoms. Doctors currently use intravenous water pills to help remove this fluid, but the process can take a long time. This study is trying to find out if adding this medication can speed up recovery and reduce how much medication patients need overall.
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If you join this study, you will be randomly assigned to receive either the combination of the two water pills or the intravenous water pill plus a placebo (fake pill) by mouth. You will take your assigned treatment twice a day for up to 3 days. The study is 'blinded,' meaning you won't know which group you're in, and neither will your doctor — this helps ensure fair results. Researchers will monitor how quickly your fluid buildup improves and how much medication you need in total.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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