Plain-English translation of NCT06475547 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Atrial Fibrillation research guide →After heart surgery, some patients develop an irregular heartbeat called atrial fibrillation. This study is investigating whether inflammation in the fat tissue surrounding the heart plays a role in causing this complication. Researchers will collect small tissue samples during surgery and analyze the genes active in those samples to identify what might trigger this irregular heartbeat in some patients but not others.
Irregular heartbeat after heart surgery is common and can lead to longer hospital stays and serious health problems. Doctors don't yet fully understand why it happens in some patients but not others. This research aims to identify the biological mechanisms—particularly those involving inflammation and heart tissue changes—so that future treatments can be better targeted and more effective.
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If you enroll, researchers will collect a small sample of the fat tissue around your heart during your scheduled cardiac surgery—this is done at the time of your operation and requires no additional procedures. Your tissue sample will then be analyzed in the laboratory using genetic sequencing to understand which genes are active and how they differ between patients who develop irregular heartbeat and those who do not. You may also be asked to provide basic health information such as age, weight, and smoking history.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
Denmark
Enrollment target
~100 participants
Started
January 2022
Primary completion
January 2027
Age range
18 Years – 99 Years
Last updated on clinicaltrials.gov in August 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Lytfi Krasniqi, MD
Odense University Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.