Plain-English translation of NCT06476067 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is looking for a way to predict which esophageal cancer patients will have their cancer come back after surgery. Researchers will examine tissue removed during your surgery to look for specific chemical patterns in your DNA that may signal whether cancer cells are likely to return. This could help doctors identify patients who need closer monitoring or additional treatment after surgery.
About 40% of esophageal cancer patients develop recurrence within two years after surgery, even when the surgery appears successful. Currently, doctors have no reliable way to predict which patients will have this happen, so this research aims to create a test based on DNA patterns that could identify high-risk patients earlier.
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Your participation is primarily based on information and tissue that already exist from your past surgery — there are no new procedures or visits required. Researchers will examine the tissue that was removed during your esophagectomy using a laboratory test called methylation-specific PCR to look for chemical markers. The study will compare patients who did and did not develop cancer recurrence to develop a predictive test for future patients.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
Japan
Sponsor
City of Hope Medical Center
Enrollment target
~150 participants
Started
January 2006
Primary completion
June 2028
Age range
20 Years and older
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Ajay Goel, PhD
City of Hope Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.