Plain-English translation of NCT06477289 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Sickle Cell Disease research guide →Researchers want to understand how sleep and blood vessel function affect thinking and brain health in young people with sickle cell disease. You'll wear two small devices overnight for three nights to measure your sleep and blood vessel activity, then visit a clinic to complete brain health assessments and imaging.
Some people with sickle cell disease experience changes in thinking and memory, but doctors don't fully understand why. This study explores whether problems with sleep and blood vessel function might be connected to these brain changes, which could lead to new ways to help.
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First, you'll complete some questionnaires at home about your sleep and health. Then you'll wear two small devices (a watch and a ring) while you sleep for three consecutive nights — data will be collected automatically. About two weeks later, you'll visit the clinic for one session where you'll do thinking and memory tests, answer questions about your behavior, and have brain imaging done. The whole study takes about a month from start to finish.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States
Enrollment target
~65 participants
Started
September 2024
Primary completion
June 2027
Age range
12 Years – 18 Years
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Andrew Heitzer, PhD
St. Jude Children's Research Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.