Plain-English translation of NCT06477549 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing two different chemotherapy drug combinations that are given before a stem cell transplant in patients with blood cancers like leukemia or myelodysplastic syndrome. The two combinations use bendamustine and in different ways alongside other standard chemotherapy drugs. The goal is to find which combination works better at preventing the transplant from failing and preventing the cancer from coming back.
Stem cell transplants from half-matched family donors can sometimes fail, meaning the new cells don't take hold or the cancer returns. This trial exists to compare two promising drug combinations that early studies suggest may reduce these serious complications.
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You will be randomly assigned to receive one of the two drug combinations. Starting about a week before your transplant, you will receive intravenous chemotherapy drugs and take oral medications over several days to prepare your body. After the stem cell infusion, you will continue taking one of the medications () for several months. You will have frequent blood tests and hospital visits during this time, as your doctors monitor how well the transplant is working and manage any side effects.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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