Plain-English translation of NCT06477692 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing a new way to deliver radiation therapy for head and neck cancer. Instead of using the standard approach that treats a larger area of the neck, researchers are using artificial intelligence to identify and target only the lymph nodes that are likely to contain cancer. The goal is to reduce radiation to healthy tissue, which could mean fewer side effects for patients.
Current radiation therapy for head and neck cancer treats a wide area of the neck to make sure no cancer is missed, but this can damage healthy tissue and cause unwanted side effects. This trial is exploring whether using artificial intelligence to be more precise and target only affected lymph nodes could maintain cancer control while reducing harm to the body.
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You will be randomly assigned to receive either the standard radiation therapy approach or the new artificial intelligence-guided approach, and you won't know which one you're receiving. Both involve radiation therapy delivered over several weeks in daily treatments. The research team will use imaging scans and the artificial intelligence program to plan your treatment, and you'll have regular follow-up visits to monitor your progress and any side effects.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
University of Texas Southwestern Medical Center
Collaborators
National Cancer Institute (NCI)
Enrollment target
~80 participants
Started
November 2024
Primary completion
July 2028
Age range
18 Years – 99 Years
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Sarah Neufeld
University of Texas Southwestern Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.