Plain-English translation of NCT06480201 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This study is testing whether a measurable pattern in your brain waves can predict whether will help your depression. Researchers will give you infusions (the medication is delivered through an IV) and use EEG—a simple, painless test that records electrical activity in your brain—to see if certain brain wave patterns show how well you might respond to treatment.
Depression that doesn't respond to regular antidepressant medications affects many people, and new treatments like show promise. However, doctors currently have no reliable way to know ahead of time who will benefit from this medication. This study aims to identify a brain-based marker that could help predict which patients are likely to improve.
You likely qualify if…
You likely don't qualify if…
If you have treatment-resistant depression, you would receive 8 infusions over several weeks (the first and fourth infusions include a placebo comparison). Each visit would include EEG brain wave recording before and after the medication to measure your brain activity. Healthy volunteers and people with standard depression would receive just one infusion session for comparison. The entire study involves multiple visits to the research facility over several weeks.
AI-generated summary from trial data · Sep 20, 2026 · Not medical advice
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