Plain-English translation of NCT06481852 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This early-stage trial is testing whether microbiota transplant therapy—a capsule containing freeze-dried healthy gut bacteria from donors—might help people with pulmonary arterial hypertension (a serious lung and heart condition). The study will also test whether adding fiber supplements helps the treatment work better. Researchers want to understand whether this medication is safe, practical, and how it affects the body.
Some recent research suggests that changes in gut bacteria may play a role in pulmonary arterial hypertension. This trial is exploring whether restoring healthy gut bacteria might be a new way to support treatment for this serious condition.
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Over 24 weeks, you will visit the study team at least 5 times (or participate via phone/video). You'll receive either the medication with fiber, the medication without fiber, or placebo capsules. Before and during the trial, you'll provide stool and blood samples, complete a six-minute walk test, have heart imaging done, and answer questions about your quality of life. The study team will track how you're doing and watch for any side effects.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
United States