Plain-English translation of NCT06483490 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are investigating how exposure to air pollution—especially fine particles in smog and exhaust—may damage lung cells and increase the risk of chronic lung disease and lung cancer. By studying tissue samples from patients with suspected lung cancer, the team hopes to understand the biological mechanisms that connect pollution exposure to these serious conditions.
Air pollution is known to be harmful to lung health, but doctors don't fully understand exactly how pollution damages lung cells at a biological level or why some people develop disease while others don't. This research aims to fill that gap so doctors can better prevent and treat pollution-related lung disease.
You likely qualify if…
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If you qualify, you will be asked to undergo a bronchial biopsy—a procedure where doctors take a small tissue sample from your lungs for laboratory analysis. This tissue will be studied to look for signs of how pollution damages lung cells and whether certain genetic structures called G-quadruplexes play a role in that damage. The study involves 200 participants total and is currently recruiting.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
Italy
Collaborators
Cardarelli Hospital
Enrollment target
~200 participants
Started
May 2023
Primary completion
May 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2024.
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Central contact
Bruno D'Agostino, MD, PhD
University of Campania Luigi Vanvitelli
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.