Plain-English translation of NCT06487429 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new treatment plan for patients with advanced stomach cancer that has not yet been treated. The approach combines short-course radiation therapy with three medications—disitamab vedotin, sintilimab, and S-1—given before surgery to shrink the tumor and improve surgical outcomes.
Advanced stomach cancer is difficult to treat, and doctors want to find better ways to help patients before surgery by shrinking tumors and making surgery more effective. This trial explores whether combining radiation with immunotherapy and targeted chemotherapy can achieve better results than existing approaches.
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You would first receive 5 days of focused radiation therapy, followed by a one-week rest. Then you would receive 3 cycles of the three medications (given every 3 weeks), with one medication delivered intravenously and another taken as oral pills. After completing all medications, you would have imaging scans to check how well the treatment worked before undergoing surgery. The entire treatment period before surgery lasts approximately 2-3 months.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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