Recruiting

Comparing minimally invasive surgery to open surgery for early cervical cancer

Plain-English translation of NCT06489795 on ClinicalTrials.gov ↗ · Source last updated February 2025 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether minimally invasive surgical techniques—using small incisions with cameras and robotic or laparoscopic tools—work as well as traditional open surgery for removing the uterus and cervix in patients with early-stage cervical cancer. Researchers want to know if the less invasive approach can achieve the same cancer control while potentially reducing pain, hospital stays, and recovery time for patients.

Currently, traditional open surgery has been the standard treatment for early cervical cancer, but minimally invasive surgery may offer patients faster recovery and less pain while being equally effective. This trial will help doctors determine whether the newer, less invasive surgical techniques are safe and effective alternatives to open surgery.

Do you qualify?

You likely qualify if…

you have been diagnosed with early-stage cervical cancer (FIGO stage IA2, IB1, or IB2)
your cancer is confirmed by biopsy as adenocarcinoma, squamous cell carcinoma, or adenosquamous carcinoma of the cervix
your tumor is less than 4 centimeters in size
you are 18 years or older and in good enough health to have surgery
you can commit to at least 5 years of follow-up visits after surgery
you have not had previous radiation therapy to the pelvis or abdomen

You likely don't qualify if…

you have advanced cervical cancer (FIGO stage IB3 or higher) or a tumor 4 centimeters or larger
you have evidence that the cancer has spread to other parts of your body or to lymph nodes larger than 2 centimeters
you have had previous radiation therapy to your pelvis or abdomen
you have a serious medical condition that would make surgery unsafe or you cannot tolerate being positioned for prolonged surgery
you have had another invasive cancer in the past 5 years (except certain skin or early breast cancers)

What participation looks like

If you qualify, you will be randomly assigned to either the minimally invasive surgery group or the traditional open surgery group. You will have one surgery to remove your uterus, cervix, and surrounding tissues, with lymph node removal as needed. After surgery, you will have follow-up visits and monitoring for at least 5 years to track your recovery and ensure the cancer does not return. The trial is recruiting patients over a 4-year period across multiple hospitals in Germany.

AI-generated summary from trial data · Aug 2, 2026 · Not medical advice

Trial locations(14 sites)

Germany

Ludwigsburg Hospital, Department of Gynecology and Obstetrics, Ludwigsburg, Baden-Wurttemberg

University Medical Center Tübingen, Department of Gynecology, Tübingen, Baden-Wurttemberg

Hochtaunus-Clinics Bad Homburg, Department of Gynecology, Bad Homburg, Hesse

University Medical Center Göttingen, Department of Gynecology and Obstetrics, Göttingen, Lower Saxony

Hannover Medical School, Department of Gynecology and Obstetrics, Hanover, Lower Saxony