Cooling wraps and medication to prevent nerve damage from cancer chemotherapy

This trial is testing whether cooling compression wraps — used before, during, and after chemotherapy infusions — can prevent peripheral neuropathy (nerve damage in the hands and feet) caused by a chemotherapy drug called paclitaxel. Some participants will also take cilostazol, a medication that improves blood flow, to see if it further reduces nerve damage. The study will compare women who use cooling wraps alone, cooling wraps plus the medication, and those receiving standard care.

Paclitaxel is an effective cancer treatment, but it commonly causes painful nerve damage that can last long after treatment ends and affect quality of life. This trial is exploring whether this medication, combined with a simple cooling strategy, can significantly reduce or prevent this side effect.