Plain-English translation of NCT06495970 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing the Gradient Denervation System, a minimally invasive procedure that uses ultrasound energy to calm the overactive nerves in your pulmonary arteries (the blood vessels carrying blood to your lungs). People with heart failure sometimes develop dangerously high pressure in these vessels, and this treatment aims to reduce that pressure and improve how you feel and function.
Some people with heart failure develop high blood pressure in the lungs that doesn't respond well to current medications alone. Researchers believe that calming the nerve signals in this area could help lower that pressure and ease symptoms like shortness of breath and fatigue.
You likely qualify if…
You likely don't qualify if…
If you enroll, you will receive the Gradient Denervation System procedure, which involves inserting a thin catheter (tube) into a blood vessel to deliver ultrasound energy to specific nerves in your pulmonary arteries. The procedure is performed in a catheterization laboratory and typically takes a few hours. After the procedure, you will have follow-up visits to monitor your recovery, check your heart and lung function, and assess how the treatment is working.
AI-generated summary from trial data · Jul 16, 2026 · Not medical advice
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