Plain-English translation of NCT06496412 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Type 1 Diabetes research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing (FMT)—a treatment where healthy gut bacteria from a donor are given to you in capsule form—to see if it can improve memory and thinking skills in people with long-standing type 1 diabetes. Researchers believe that the bacteria in our gut may affect how our brain works, and this study will measure whether the treatment helps with thinking, memory, and other complications of diabetes over 24 weeks. Half of participants will receive the actual treatment, and half will receive placebo capsules that look identical.
People with type 1 diabetes for many years sometimes experience problems with memory and thinking. Scientists have discovered that the bacteria living in our digestive system may play a role in brain health, so this medication offers a new way to potentially improve these symptoms and other diabetes-related complications.
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You will be randomly assigned to receive either the treatment or placebo capsules. Over 24 weeks, you'll take a large dose of 50 capsules at the start, then smaller maintenance doses at weeks 2, 4, 8, 12, and 20. You'll need to fast for 4 hours before taking the capsules and 1 hour after, and keep your diet and exercise stable throughout the study. The research team will monitor your thinking and memory using brain imaging (MRI) and cognitive tests, check your blood sugar control, measure insulin use, examine your blood cells and metabolites, and assess other diabetes-related complications at baseline and at week 24.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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