Plain-English translation of NCT06496646 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is looking at how people use antidepressants and what helps them take their medication as prescribed. Researchers will give you a special pill bottle that tracks when you open it to take your medication. By learning more about what helps or prevents people from taking the medication regularly, doctors hope to improve depression treatment in the future.
Many people with depression struggle to take their medication consistently, which can affect how well it works. This study aims to understand the barriers and supports around taking the medication regularly so doctors can help patients succeed with their treatment.
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You'll receive a special pill bottle for your depression medication that automatically tracks when you open it. Over 12 weeks, you'll have an initial phone call to answer questions about your mood and depression management, then follow-up calls or online check-ins at 6 weeks and 12 weeks. The research team will ask you about how you're feeling, your quality of life, and how you're managing your depression.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
United States
Sponsor
University of Pennsylvania
Enrollment target
~525 participants
Started
March 2025
Primary completion
March 2029
Age range
21 Years – 64 Years
Last updated on clinicaltrials.gov in November 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Steven C Marcus, PhD
University of Pennsylvania
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.