Combining ultrasound with standard brain tumor medication for recurrent glioblastoma

This trial is testing whether combining Avastin (a medication that slows tumor growth) with a new ultrasound-based technique called NaviFUS System can help people whose glioblastoma has come back after radiation and chemotherapy. Half of the participants will receive the medication alone, while the other half will receive the medication plus the ultrasound treatment. Researchers want to see if adding this ultrasound technology makes the medication work better against the cancer.

Glioblastoma is an aggressive brain cancer, and when it returns after initial treatment, options become limited. This new treatment aims to improve outcomes by using focused ultrasound waves to help the medication reach and penetrate the tumor more effectively than the medication can do on its own.