Testing a simpler two-drug HIV treatment for people with both HIV and tuberculosis

This trial is testing whether dolutegravir/lamivudine (a two-drug HIV treatment) works as well as the standard three-drug combination for people who have just been diagnosed with HIV and also have tuberculosis. You would take one of these medication regimens while you're being treated for your tuberculosis infection, to see if the simpler two-drug approach can control your HIV as effectively as the three-drug approach.

Tuberculosis is the most common cause of death in people with HIV worldwide. Doctors need to treat both diseases at the same time, but the current standard three-drug HIV regimen can be expensive, hard to take every day, and may cause long-term side effects. This trial is looking at whether a simpler two-drug treatment can work just as well while being easier to take and potentially safer over time.