Plain-English translation of NCT06504589 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Cystic Fibrosis research guide →This is an observational study — meaning researchers will track your cystic fibrosis health over time without giving you a new medication to test. The study is designed for people with CF who are genetically unable to benefit from CFTR modulators (the current main CF medications) or who have chosen not to take them. By collecting detailed health information from your regular clinic visits and tests, researchers hope to better understand your disease and use this data to develop and test new treatments specifically for people in your situation.
About 90% of people with cystic fibrosis in the United States now benefit from newer medications called CFTR modulators. However, the remaining 10% — people who are genetically ineligible or not taking these medications — have been left behind. New treatments are being developed for this group, including gene-based therapies and treatments targeting CF symptoms, but researchers need good health data from people like you to test these new options fairly and effectively.
You likely qualify if…
You likely don't qualify if…
You will visit the research clinic at regular intervals over 12 months. At these visits, researchers will collect information from your medical records, ask you questions about your health, and may ask you to complete some specialized tests or measures related to your CF. You won't receive a new medication as part of this study — instead, your regular CF care continues as normal while researchers monitor and document your health. The data collected will help researchers understand your condition better and develop new treatments for people in your situation.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States