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Take one of two medications to slow your heart rate for two months | stella

Back to Treatment Resistant Schizophrenia trials

Recruiting

Comparing two heart rate medications for people on clozapine

Plain-English translation of NCT06505668 on ClinicalTrials.gov ↗ · Source last updated July 2024 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

When people with treatment-resistant schizophrenia take clozapine — a powerful antipsychotic medication — about one in three experience a persistently fast heartbeat as a side effect. This study is testing whether atenolol or ivabradine, two different heart rate medications, can safely and effectively slow the heart down. Researchers want to find the best option to help people stay on clozapine without this uncomfortable and potentially risky side effect.

Many people with severe schizophrenia stop taking clozapine because of the rapid heartbeat it causes, even though it's the most effective treatment for their condition. This trial aims to find a safe way to manage this side effect so patients can continue benefiting from the medication.

Do you qualify?

You likely qualify if…

you have been diagnosed with treatment-resistant schizophrenia and are currently taking clozapine
you are between 18 and 60 years old
your resting heart rate is over 100 beats per minute
you are able to provide written informed consent (or have a legally authorized representative who can)

You likely don't qualify if…

you are already taking atenolol or ivabradine
you have a medical reason why you cannot safely take either of these heart rate medications
you are taking other medications (besides clozapine) known to affect your nervous system
you are actively using drugs or alcohol
you have serious medical or neurological conditions in addition to schizophrenia

What participation looks like

You will be randomly assigned to take either atenolol or ivabradine once or twice daily for two months. During this time, you will continue taking your clozapine as prescribed. The research team will monitor your heart rate and overall health through visits and may check your blood work to ensure the treatment is working safely and not causing problems.

AI-generated summary from trial data · Jun 19, 2026 · Not medical advice

Trial locations(1 site)

India

All India Institute of Medical Sciences, Bhubaneswar, Odisha

Key details

Sponsor

All India Institute of Medical Sciences, Bhubaneswar

Enrollment target

~40 participants

Started

August 2023

Primary completion

June 2025

This trial's estimated completion date has passed — the record may not be fully up to date.

Age range

18 Years – 60 Years

Last updated on clinicaltrials.gov in July 2024.

Contact the research team directly

Reach out to the team running this trial. Response times vary — some teams are faster than others.

Central contact

Biswa R Mishra, MD, DPM

Professor and Head, Department of Psychiatry

Interested in joining?

Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.

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View full record on ClinicalTrials.gov