Plain-English translation of NCT06511310 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers at Joslin Diabetes Center want to understand how exercise affects your brain's control of hunger and weight, especially if you've gained weight back after weight-loss surgery. You'll complete brain imaging scans before and after a 12-week program of high-intensity interval training—short bursts of hard exercise followed by easier recovery periods. The study aims to learn whether this type of exercise can help rewire how your brain manages appetite and keeps weight off long-term.
Many people who have bariatric surgery regain a significant amount of weight afterward, and doctors don't fully understand why or how to prevent it. This study hopes to discover whether exercise can change brain activity in ways that naturally reduce hunger and support lasting weight control.
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You'll visit the clinic three times before starting the exercise program for baseline tests including blood work, a glucose tolerance test, a fitness assessment, and a brain imaging scan (MRI). Then you'll exercise four times per week for 12 weeks, with sessions consisting of short bursts of intense effort alternating with easier recovery periods—each session lasts about 28 minutes and can be done at Joslin or at home. After completing the 12-week program, you'll return for three final clinic visits to repeat all the initial tests so researchers can see how the exercise changed your brain activity and weight regulation.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Sponsor
Joslin Diabetes Center
Collaborators
Nutrition Obesity Research Center
Enrollment target
~15 participants
Started
September 2025
Primary completion
July 2026
Age range
18 Years – 70 Years
Last updated on clinicaltrials.gov in September 2025.
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Central contact
Maria Vamvini, MD
Joslin Diabetes Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.