Plain-English translation of NCT06514365 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
After knee replacement surgery, patients often experience significant pain, especially during movement, which can lead to long-term chronic pain problems. This study compares two different nerve block techniques—both using bupivacaine, a local anesthetic—to see which one works better at controlling pain and allowing patients to move and rehabilitate sooner after surgery.
Doctors want to find the best way to block pain after knee replacement while minimizing weakness in the leg so patients can start physical therapy and healing as quickly as possible. This study compares two newer nerve block approaches to determine which one provides better pain relief with fewer side effects.
You would undergo total knee replacement surgery using regional anesthesia (numbing of the nerves in your leg). During surgery, you would receive one of two nerve block techniques—either a block targeting the sciatic nerve in the back of your knee, or a block in the space around the popliteal artery behind the knee. After surgery, your pain levels and ability to move would be monitored to compare how well each technique works.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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