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Testing fiber supplements to reduce inflammation in ulcerative colitis

Plain-English translation of NCT06515210 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Read our Ulcerative Colitis research guide →

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This study is testing whether dietary fiber supplements can help people with ulcerative colitis by changing the bacteria in their gut and reducing inflammation. Researchers will compare two different types of fiber — Acacia gum (a fermentable fiber) and microcrystalline cellulose (a non-fermentable fiber) — to see which might work better as a complement to your current medications.

Many people with ulcerative colitis struggle with long-term inflammation even while taking strong medications that can have side effects. This treatment aims to offer a safer, natural way to support healing by targeting the gut bacteria that may contribute to the disease.

Do you qualify?

You likely qualify if…

you have been diagnosed with ulcerative colitis and have active disease (confirmed by blood tests or symptom scores)
you are at least a teenager (Tanner stage 4) and weigh more than 40 kg
you have been on stable ulcerative colitis medications for at least three months with no major changes
you are able to stick with your current diet, exercise, supplements, and medications throughout the study
you are willing and able to take fiber supplements daily for six weeks

You likely don't qualify if…

you have Crohn's disease, other types of inflammatory bowel disease, or bowel conditions like celiac disease
you have a history of severe heart disease, cancer, kidney disease, diabetes, or other serious chronic illnesses
you have taken antibiotics for more than a week in the past two months or are planning to use them during the study
you are currently using probiotics, prebiotics, or fiber supplements that affect your gut bacteria
you are regularly taking opioid pain medications, anti-diarrheal medications, or laxatives

What participation looks like

You will take either Acacia gum or microcrystalline cellulose fiber supplements daily for six weeks (with a higher dose after the first two days). You'll start with a smaller dose to let your body adjust. The study team will monitor how you respond and may ask you to continue for another six weeks if you choose. Throughout the study, you'll keep your current medications and lifestyle the same so researchers can see how much the fiber helps.

AI-generated summary from trial data · Jun 11, 2026 · Not medical advice

Testing fiber supplements to reduce inflammation in ulcerative colitis

What is this trial?

Do you qualify?

What participation looks like

Trial locations