Plain-English translation of NCT06516822 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The SINUS trial is testing whether adding extra ablation steps to a standard heart rhythm procedure improves outcomes for people with long-standing persistent atrial fibrillation — a serious condition where the heart's upper chambers beat irregularly and don't respond well to medications. Half of the 320 participants will receive a standard ablation procedure that isolates the pulmonary veins, while the other half will receive the same procedure plus additional ablation steps to several other areas of the heart. Researchers will track participants for at least 12 months to see which approach works better at stopping abnormal heart rhythms.
Long-standing persistent atrial fibrillation is difficult to treat and often fails with medication alone. This trial exists to determine whether adding extra ablation steps during the procedure can help more patients achieve a normal heart rhythm and stay free from this condition.
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If you enroll, you will be randomly assigned to receive either the standard ablation procedure or the standard procedure plus additional ablation steps. Both procedures are performed using catheters (thin tubes) guided to your heart. After the procedure, you will have follow-up appointments and heart rhythm monitoring for at least 12 months to check whether the abnormal rhythms have stopped and whether you can reduce or stop your heart rhythm medications.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
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