Plain-English translation of NCT06526689 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand how your lungs' immune system reacts when you're first exposed to tuberculosis—before you even develop symptoms. By collecting sputum (spit) and blood samples from people who've recently been in close contact with someone who has active tuberculosis, they hope to learn what happens in the early immune response and why some people never develop the infection while others do.
Tuberculosis kills more people worldwide than any other single infectious disease, and we still don't have an effective vaccine to prevent it. Scientists don't fully understand the very early immune response in the lungs because it happens before people feel sick, making it hard to study. This research could reveal how some people naturally resist developing tuberculosis, which might help us design better vaccines and treatments.
You likely qualify if…
You likely don't qualify if…
If you qualify, you'll be asked to provide sputum samples (by coughing into a container) and blood samples at study visits. Researchers will measure the immune cells in your samples and track how they change over time, comparing what's happening in your airways to what's happening in your blood. The study involves visits to the research center in London or Oxford, though the exact number and timing of visits will depend on which group you're in.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United Kingdom
Sponsor
University of Oxford
Collaborators
University College, London
Enrollment target
~50 participants
Started
August 2024
Primary completion
October 2026
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in January 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Timothy Fredsgaard-Jones, MBBS
University of Oxford
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.