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Try new tools designed to improve your heart failure treatment plan | stella

Back to Heart Failure With Reduced Ejection Fraction trials

Recruiting

Testing tools to help heart failure patients get better medicines

Plain-English translation of NCT06526988 on ClinicalTrials.gov ↗ · Source last updated June 2025 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

I-I-CAPTAIN-HF is testing two tools designed to help you and your doctor work together to optimize your heart failure treatment. Some patients will receive an educational video and checklist about heart medications before their appointments, doctors will receive alerts reminding them to prescribe guideline-recommended medicines, or both groups will receive both tools. The study involves about 2,200 patients at five major medical centers.

Many patients with reduced heart function aren't receiving all four key medications that doctors know help them live longer and feel better. This study aims to see whether patient education materials and automated reminders to doctors can close that gap and ensure more people get the full, proven treatment they need.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with heart failure with reduced ejection fraction (your heart pumping strength is 40% or lower)
you have had a cardiology appointment in the past 12 months
you are not currently taking all four classes of heart failure medications at their full doses

You likely don't qualify if…

you have a left ventricular assist device (mechanical heart pump)
you are being evaluated for or are on a waiting list for a heart transplant
you have severe kidney disease (GFR less than 15)
you are receiving IV heart medications or hospice care
you do not speak English or Spanish

What participation looks like

Depending on which group you're randomly assigned to, you may receive an educational video and checklist to review before your regular cardiology appointments, your doctor may receive alerts about recommended medications during your visits, or both. The study will track how these tools help you and your doctor manage your heart failure treatment over time. All participation happens during your regular clinic visits—no extra procedures or hospital stays are required.

AI-generated summary from trial data · Jun 19, 2026 · Not medical advice

Trial locations(5 sites)

United States

Sutter Health, Walnut Creek, California

University of Colorado, Aurora, Colorado

Yale University, New Haven, Connecticut

Northwestern University, Chicago, Illinois

University of Utah, Salt Lake City, Utah

Key details

Sponsor

University of Colorado, Denver

Collaborators

Patient-Centered Outcomes Research Institute, Yale University

Enrollment target

~2,200 participants

Started

March 2025

Primary completion

September 2028

Age range

18 Years and older

Last updated on clinicaltrials.gov in June 2025.

Contact the research team directly

Reach out to the team running this trial. Response times vary — some teams are faster than others.

Central contact

Larry A Allen, MD, MHS

University of Colorado, Denver

Interested in joining?

Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.

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View full record on ClinicalTrials.gov