Plain-English translation of NCT06527183 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers have noticed that many fibromyalgia patients have damage to their small nerve fibers, but they don't fully understand how this damage causes the pain and other symptoms. This study will examine nerve fiber damage in fibromyalgia patients using skin biopsies and several specialized tests, then compare these findings to people with other types of chronic pain and to healthy people without pain.
Small fiber neuropathy (damage to tiny nerves) appears common in fibromyalgia, but doctors don't yet know whether this nerve damage is the main cause of fibromyalgia pain or just something that happens alongside it. This research aims to clarify that relationship so treatments can be better targeted.
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You will have a small skin biopsy taken (a tiny sample of skin to examine the nerve fibers under a microscope) and complete four non-invasive tests that measure how your nerves sense temperature, touch, and other sensations. These tests include quantitative sensory testing, laser evoked potential recordings, a sweat gland function test (Sudoscan), and a microscopy exam of nerves in your eye. The study compares results between fibromyalgia patients, people with other chronic pain conditions, and healthy volunteers to see if nerve damage patterns differ.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
France