Recruiting

Sexual health and hormone effects during lung cancer treatment

Plain-English translation of NCT06532149 on ClinicalTrials.gov ↗ · Source last updated August 2024 · Translation generated July 2026 · How we translate trials

What is this trial?

This study looks at how modern lung cancer treatments affect men's sexual health and hormone levels. Researchers want to understand whether different types of cancer therapy—including targeted drugs, immunotherapy, and chemotherapy—cause problems with sexual function or hormone imbalances. This information will help doctors better prepare patients and manage side effects.

Men with advanced lung cancer now live longer because of newer, more effective treatments, but doctors don't know much about how these medications affect sexual health and fertility in the long term. This study exists to fill that gap so doctors can support patients better.

Do you qualify?

You likely qualify if…

you have been diagnosed with advanced or metastatic non-small cell lung cancer
you are about to start or are currently receiving active cancer treatment
you are between 18 and 75 years old
you have been sexually active within the past 30 days before your treatment starts
you are well enough to participate (Eastern Cooperative Oncology Group performance status 0–1)
you can provide written informed consent

You likely don't qualify if…

you have a history of hormone disorders (except well-controlled thyroid disease treated for at least 2 years)
you have medical conditions that would interfere with sexual activity or make study participation unsafe, such as spinal cord problems or cancer spread to certain areas
you are taking medications known to affect male sexual function, such as opioids, certain antidepressants, anti-anxiety drugs, or beta-blockers
you have not fully recovered from previous chemotherapy-related damage to your reproductive organs
you have a serious psychiatric disorder, substance abuse problem, or untreated psychological distress that would interfere with your ability to participate

What participation looks like

You would be placed into one of four groups based on the specific type of lung cancer treatment you are receiving. Throughout your cancer treatment, you would complete surveys and blood tests to measure hormone levels and assess your sexual health at set time points. The study does not require you to take any new medication—researchers are simply observing and documenting how your current cancer treatment affects these aspects of your health.

AI-generated summary from trial data · Jul 3, 2026 · Not medical advice

Trial locations(1 site)

Italy

Fondazione Policlinico Gemelli IRCCS, Rome