Plain-English translation of NCT06541691 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing two different forms of aspirin — a regular version and a specially coated version — to see which one works better at preventing heart attacks, strokes, and other cardiovascular events in people who already have heart or blood vessel disease. It's also testing whether simple, everyday actions (like wearing masks on polluted days, staying indoors when air quality is poor, and eating citrus fruits) can help protect your heart from the harmful effects of air pollution.
Doctors prescribe aspirin to help prevent future heart problems in people with existing heart disease, but it can upset your stomach. A coated version might be gentler, but researchers aren't sure if it works as well. At the same time, air pollution causes serious heart problems worldwide, but no one has tested whether practical, patient-friendly strategies can actually reduce that damage.
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You will be randomly assigned to take either regular aspirin or coated aspirin, with or without a set of protective strategies against air pollution. Some participants will receive text message alerts on high-pollution days reminding them to stay indoors or wear masks, along with an educational card and recommendations to eat citrus fruits on those days; others will receive standard care with no specific air pollution guidance. You'll continue taking your assigned aspirin daily while the study team follows your health over time to see if either aspirin type or the protective strategies help prevent heart problems.
AI-generated summary from trial data · Jul 19, 2026 · Not medical advice
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