Plain-English translation of NCT06542094 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study uses deep brain stimulation — a surgical procedure where a small device is implanted to monitor and record electrical signals from your brain — to help understand why some people's depression doesn't respond to typical medications. Researchers will use advanced computer analysis to find patterns in these brain signals that are linked to depression symptoms, with the goal of creating personalized treatments that work better for people with treatment-resistant depression.
About 30% of people with major depression don't get better with standard antidepressants or talk therapy, and doctors currently lack reliable brain-based markers to guide treatment decisions. This trial exists to discover objective patterns in brain activity that could help doctors predict and treat depression more effectively in the future.
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You would undergo brain surgery to have a small recording device implanted, which would then collect electrical signals from your brain over a period of time. During this time, researchers would monitor your depression symptoms and the brain signals together, using advanced computer analysis to find patterns. The study involves 12 participants total, and you would be required to attend regular appointments for monitoring and to allow researchers to safely collect and analyze your brain data.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
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