Plain-English translation of NCT06543576 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing whether combining radiation therapy with chemotherapy and two immunotherapy medicines — and — can help people with advanced cervical cancer that has spread beyond the pelvis. The study will check if this combination is safe to use together and whether it helps people live longer and respond better to treatment.
Advanced cervical cancer that has spread is very difficult to treat, and current standard treatments don't work well enough for all patients. Researchers want to see if adding radiation therapy to immunotherapy and chemotherapy can improve survival and help more patients respond to treatment.
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You would receive chemotherapy and immunotherapy infusions every 3 weeks for 6 cycles (about 4.5 months), followed by a 3-week break. Then you would receive external beam radiation therapy (25 treatments over 5 weeks) and internal radiation (brachytherapy), while continuing immunotherapy infusions every 3 weeks for up to 2 years total. Throughout the study, you would have regular imaging scans (CT, PET, or MRI) and blood tests to monitor how you're responding to treatment.
AI-generated summary from trial data · Aug 2, 2026 · Not medical advice
United States