Plain-English translation of NCT06550674 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers are trying to identify new genes that may increase the risk of uveal melanoma — a rare cancer of the eye — especially in families where the disease runs in multiple relatives. Currently, scientists only understand about 20% of cases where uveal melanoma appears to be hereditary, meaning there are likely unknown genetic causes still to be discovered. This study asks participants with uveal melanoma to donate a blood sample for genetic analysis to help find these missing genetic clues.
Most people with uveal melanoma don't have a known genetic cause, even when the cancer appears to run in their family. Additionally, researchers have noticed that families with uveal melanoma also seem to have higher rates of other cancers like prostate, thyroid, and leukemia — cancers not typically linked to the few known uveal melanoma genes. Identifying new genetic causes could help doctors offer better screening and surveillance to at-risk families.
You likely qualify if…
You likely don't qualify if…
If you qualify, you would provide a blood sample for genetic analysis. The researchers will examine your DNA to look for new gene mutations that may increase melanoma risk. If they find a significant genetic variant, they may ask you to provide a second sample (a cheek swab) to confirm their findings. The study involves a single visit for blood collection and genetic testing.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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