Adding a liver-targeted treatment to chemotherapy for colorectal cancer that has spread to the liver

This trial is testing whether adding irinotecan-loaded drug-eluting beads (DEBIRI)—a medication that targets cancer in the liver directly—to standard chemotherapy works better than chemotherapy alone for colorectal cancer that has spread to the liver. The medication is delivered directly to the liver using a special procedure. Researchers want to see if this combination helps more patients become candidates for surgery to remove the remaining cancer.

When colorectal cancer spreads to the liver, surgery to remove it isn't always possible right away. This trial exists to find out whether this new liver-targeted treatment can shrink the cancer enough to make surgery possible, which could offer patients a better chance at long-term survival.