Recruiting

Using AI to detect heart failure worsening through sound recordings

Plain-English translation of NCT06555757 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated August 2026 · How we translate trials

What is this trial?

Researchers are testing whether a smartphone app that listens to your sounds—like your breathing and cough—can use artificial intelligence to predict when your heart failure might suddenly get worse. This study involves 250 people with moderate to severe heart failure who will record sounds using their own smartphone or a loaned device. The goal is to catch problems early so doctors can help you before you end up in the hospital.

Heart failure often gets suddenly worse (called acute decompensation), which is a medical emergency that usually means hospitalization. If doctors could spot warning signs earlier through simple sound recordings, they could treat you in the community and prevent costly hospital visits.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with chronic stable heart failure at a moderate to severe level (NYHA Class 3 or 4)
you have a smartphone or are willing to use a loaned smartphone device to make sound recordings
you are able and willing to give informed consent to participate

You likely don't qualify if…

you have active pneumonia at the time of recording
you have significant lung disease including asthma, COPD, or pulmonary fibrosis
you are currently needing high-flow oxygen therapy that cannot be given through a nose tube
you have had surgery on your head, neck, or vocal cords that affects how you sound
you have another acute illness (like a viral or bacterial infection) at the time of recording

What participation looks like

You will download a smartphone app (or use a loaned phone) to record simple sound samples—such as your breathing, cough, or voice—at regular intervals. The study team will guide you on how to use the app. Your recordings will be analyzed by artificial intelligence to look for patterns that might signal your heart failure is worsening, helping doctors intervene early before an emergency happens.

Using AI to detect heart failure worsening through sound recordings

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)