Plain-English translation of NCT06555952 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Hypertension research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether MegaNatural BP®, a supplement made from grape seeds, can help lower blood pressure in people with elevated readings. Earlier research suggested that 300 mg per day of this extract might reduce blood pressure, but the researchers now want to see if a smaller dose of 150 mg per day works just as well. The medication may also help improve how your body uses insulin, which could be beneficial if you're showing early signs of prediabetes.
Many people have high blood pressure and early metabolic problems like prediabetes, and not everyone wants to take prescription medications right away. This trial exists to find out whether a natural supplement could be an effective and gentler option to help manage these conditions.
You likely qualify if…
You likely don't qualify if…
You would visit the Clinical Nutrition Research Center 7 times over 6 weeks. At your first visit, the team will check your height, weight, blood pressure, and blood sugar to confirm you qualify. You'll then receive a small device to wear that measures your blood pressure throughout the day, and you'll take either the grape seed supplement or a placebo (dummy pill) daily for the study period. During four study visits, the researchers will draw blood to check how your body processes insulin and use ultrasound to measure how flexible your blood vessels are. You'll also need to keep a food diary and avoid alcohol and intense exercise for 24 hours before each visit.
AI-generated summary from trial data · Jun 8, 2026 · Not medical advice
United States