Plain-English translation of NCT06562608 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Schizophrenia research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether stopping benztropine or trihexyphenidyl — medications sometimes prescribed long-term for schizophrenia — can actually help people think more clearly and feel better if the medication is no longer medically necessary. Researchers will compare people who safely stop the medication with people who continue taking it, measuring changes in thinking ability, daily functioning, and quality of life over 6 months.
Many people with schizophrenia have been on these medications for years, but doctors aren't always sure whether the medication is still needed or helping. This study wants to find out whether stopping the medication—when it's safe to do so—might actually improve memory, concentration, and overall well-being.
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You'll have an initial visit where researchers will do tests and take brain imaging scans (an MRI). Then you'll be randomly assigned to either stop the medication gradually under your doctor's care, or continue taking it as usual. Over the next 6 months, you'll return for follow-up visits where researchers will test your memory and thinking, ask how you're functioning day-to-day, and check how you're doing overall.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States