Recruiting

Testing a new skin medication for eczema in healthy adults and patients

Plain-English translation of NCT06564389 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

This is one of the first times this treatment has been tested in people.

What is this trial?

This is a first-in-human trial of , a new experimental medication being tested to see if it is safe and works well for people with moderate to severe atopic dermatitis (eczema). The study has two parts: first, healthy adults will receive the medication to check for safety and how the body processes it; then, people with moderate to severe eczema will receive the medication to learn if it actually helps their skin condition.

Atopic dermatitis is a chronic skin condition that causes intense itching and discomfort, and many patients do not respond well enough to currently available treatments. This trial is testing a new medication to offer patients a potentially better treatment option.

Do you qualify?

You likely qualify if…

you are between 18 and 55 years old (if enrolling as a healthy volunteer) or between 18 and 70 years old (if you have eczema)
you are in overall good health with a normal weight range (BMI 17.5 to 40)
if you have eczema, you must have been diagnosed at least one year ago and have moderate to severe symptoms that cover at least 10% of your skin
if you have eczema, you must have tried standard treatments (like creams) without good results, or have a medical reason why you cannot use them
you do not have active infections, tuberculosis, cancer, or serious heart, lung, kidney, or liver disease

You likely don't qualify if…

you have a history of tuberculosis (active or untreated latent infection)
you have had a serious infection requiring hospitalization or have a blood cancer or lymph node disorder
you have had major surgery or serious injury within one month before starting the study
you have other active skin conditions (besides eczema in Part 2) that would interfere with assessing the medication's effects
you are pregnant, breastfeeding, or unable to use reliable birth control during the study

What participation looks like

If you qualify, you will be randomly assigned to receive either the new medication or a placebo (inactive treatment) at scheduled visits. In Part 1 (for healthy volunteers), you will receive a single dose or multiple doses over time and have blood tests and physical exams to check safety. In Part 2 (for patients with eczema), you will receive the medication or placebo and have your skin assessed to see if symptoms improve. Throughout the study, you will have regular check-ins with doctors and blood work to monitor how your body is handling the treatment.

AI-generated summary from trial data · Jun 9, 2026 · Not medical advice

Trial locations(3 sites)

United States

Anaheim Clinical Trials, LLC, Anaheim, California

Miami Dermatology and Laser Research, Miami, Florida

Paddington Testing Company, Philadelphia, Pennsylvania