Plain-English translation of NCT06570421 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This is a 24-month study testing the long-term safety and effectiveness of a home-based nerve stimulation device called peroneal eTNM that you use yourself at home. The device sends mild electrical signals through the skin on your leg to help reduce tremor and movement problems in people with Parkinson's disease or essential tremor. A shorter 6-week pilot study showed the treatment was safe, well-tolerated, and patients were able to use it on their own with very high adherence rates.
A recent shorter study showed promising results for reducing tremor in people with these movement disorders, and patients even experienced improvement that lasted weeks after stopping treatment. This longer study wants to confirm the treatment remains safe and effective over a full two years, and to understand whether the benefits last over the long term.
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You will use a home nerve stimulation device called URIS I for 24 months, applying it to your leg at regular intervals as instructed. The earlier pilot study showed patients could easily use this device at home on their own. You will have study visits where researchers check on your tremor using movement tests and ask about any side effects or concerns, and they will track how well the treatment is working over the two-year period.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
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