Testing Pig Pancreas Cells to Help Type 1 Diabetes Patients

Plain-English translation of NCT06575426 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

Read our Diabetes Mellitus, Type 1 research guide →

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This is the first human study of OPF-310, which uses pancreas cells from pigs that are specially enclosed in a protective capsule and then transplanted into your body. The goal is to help your body produce insulin naturally and reduce dangerous drops in blood sugar. Researchers want to understand how safe this treatment is and whether it works to improve blood sugar control in people with type 1 diabetes that hasn't responded well to current treatments.

Many people with type 1 diabetes struggle to keep their blood sugar stable, even when using the most advanced insulin pumps and glucose monitors available. They experience scary, severe low blood sugar episodes that can be dangerous and hard to predict. This medication is being tested as a potential way to give the body a source of insulin-producing cells that could help prevent these dangerous lows.

Do you qualify?

You likely qualify if…

you are between 35 and 65 years old
you have had type 1 diabetes for at least 5 years
you have unstable type 1 diabetes that is not well controlled even with advanced insulin pump and glucose monitoring systems for at least 6 months
you have had at least three severe low blood sugar episodes (where you needed help from someone else to recover) in the past year, or one severe episode plus a high impairment score on a standard test
you have very little or no insulin production remaining in your pancreas

You likely don't qualify if…

you have needed very high doses of insulin (more than 0.8 units per kilogram of body weight daily) in the week before enrollment
you have a related form of diabetes other than type 1 (such as LADA, Flatbush diabetes, or MODY)
you have active cancer or a history of cancer in the past 5 years (except for skin cancer)
you have an untreated or unstable thyroid condition
you have a positive test for HIV or other serious infections

What participation looks like

If you join this study, you will receive a transplant surgery to implant the encapsulated pig pancreas cells into your body. After the transplant, you will need to visit the research team regularly so they can monitor how well the cells are working and watch for any side effects. You will also need to commit to lifelong follow-up care and monitoring to ensure the transplant continues to work safely.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Testing Pig Pancreas Cells to Help Type 1 Diabetes Patients

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)