Plain-English translation of NCT06575738 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is studying what happens to your body after weight-loss surgery (specifically a procedure called vertical sleeve gastrectomy) in people ages 12 to 24. Researchers want to understand why some people lose more weight than others after surgery and how to measure success in different ways. The study also tests whether a medication called semaglutide can help people who haven't lost enough weight between 1 and 2 years after their surgery.
Weight-loss surgery doesn't work the same way for everyone, and some young people don't lose as much weight as doctors hope. Doctors need to better understand how to predict who will benefit most from surgery and whether this medication can help those who need extra support.
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If you join the observation phase, you'll complete standard health assessments before surgery, 3 months after surgery, and 12 months after surgery. If you're in the medication phase, you'll receive usual postoperative care plus weekly injections of the medication for 26 weeks, with the dose gradually increasing every 4 weeks as your body tolerates it. Throughout the study, you'll work with a team of healthcare providers and attend regular visits to monitor your progress.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
United States