Plain-English translation of NCT06576180 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is watching how a combination of chemotherapy drugs (carboplatin and paclitaxel) plus immunotherapy () affects your thinking, memory, and brain function in people with head and neck cancer. Researchers will compare people who receive this combination treatment before surgery to those who have surgery alone, and also to healthy people without cancer. The goal is to understand whether these medicines impact how your brain works.
Cancer treatments can sometimes affect thinking and memory, but we don't know much about how this particular combination of medications impacts brain function in head and neck cancer patients. This study will help doctors understand these risks so they can better prepare and support patients who choose this treatment.
If you join, you'll be in one of three groups: people receiving chemotherapy and immunotherapy before surgery, people having surgery alone, or healthy volunteers. You'll complete tests of your thinking and memory at different time points—before treatment, during treatment, and after surgery. These tests might include questionnaires, interviews, or cognitive assessments to measure how well your memory and concentration are working.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
China
Sponsor
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Enrollment target
~306 participants
Started
August 2024
Primary completion
September 2024
Age range
18 Years – 80 Years
Last updated on clinicaltrials.gov in August 2024.