Tracking biological markers in ALS patients over two years

Plain-English translation of NCT06578195 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated June 2026 · How we translate trials

What is this trial?

The ASSESS ALL ALS study is a large research effort collecting biological samples, medical records, and health information from people diagnosed with ALS and healthy volunteers. Researchers will follow participants for two years, gathering blood samples, speech recordings, and patient-reported information to build a database that will help scientists understand ALS better and develop new treatments.

Right now, there are limited biological markers—measurable signs in the blood or other body fluids—that help researchers track how ALS progresses or predict how the disease will affect different people. By collecting samples and information from thousands of participants over time, this study aims to identify these markers and accelerate the discovery of new treatments.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with ALS by a physician (for ALS participants) or you do not have ALS or related neurological conditions (for control participants)
you are able to understand the study and give your informed consent
you have access to a smartphone, computer, tablet, or internet connection (even at a library or public location)
you are willing to follow the study procedures for two years

You likely don't qualify if…

you have significant cognitive impairment, dementia, or unstable psychiatric illness that would make it hard to participate
you are dealing with a serious unstable medical condition (other than ALS) that might prevent you from completing the study
you have untreated major depression within the last 90 days
you have active suicidal thoughts or a recent suicide attempt
you have a family history of inherited ALS or related conditions (unless you've already tested negative for the genetic cause)

What participation looks like

Depending on which group you join, you may visit a clinic in person or participate remotely through video calls. Either way, you'll provide blood samples every four months, complete monthly health surveys and voice recordings, and share your medical history. The study lasts two years, and some participants at clinical sites may optionally provide additional fluid samples through a lumbar puncture procedure.

AI-generated summary from trial data · Jun 26, 2026 · Not medical advice

Tracking biological markers in ALS patients over two years

What is this trial?

Do you qualify?

What participation looks like

Trial locations(37 sites)