Tracking biomarkers and health changes in ALS patients over two years

Plain-English translation of NCT06578195 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated September 2026 · How we translate trials

What is this trial?

The ASSESS ALL ALS study is a long-term research project that collects blood samples, medical information, and voice recordings from people diagnosed with ALS, as well as healthy volunteers who serve as comparison participants. Researchers across the country are working together to gather and share this information with the scientific community, hoping to better understand ALS and develop new treatments.

Right now, there are no reliable biological markers—measurable signs in the blood or body—that can help doctors track how ALS progresses or predict how individual patients will respond. By collecting samples and health data from many people over time, researchers hope to discover these markers and use them to design better, faster clinical trials.

Do you qualify?

You likely qualify if…

you are 18 years of age or older
you have been diagnosed with ALS by a doctor (or you are a healthy volunteer without ALS or related neurological conditions)
you are able to understand the study and give your informed consent
you have access to a smartphone, computer, or tablet with internet (including public library access)
you are willing to participate in study visits and follow the study procedures for two years

You likely don't qualify if…

you have significant cognitive impairment, untreated depression, active suicidal thoughts, or unstable psychiatric illness
you have an unstable medical condition (such as heart problems, infection, or untreated thyroid disease) that would prevent you from completing the study
you have a close family member with inherited ALS or a genetic ALS mutation, unless you have already tested negative for known ALS genes
you are currently pregnant (if participating in the optional spinal fluid collection)

What participation looks like

You can participate either by visiting one of 35 research clinics in person or by joining remotely through video calls and home blood draws. Over two years, you'll have blood drawn every four months, complete monthly health surveys and voice recordings from home, and share your medical history and health updates. Some participants visiting clinics may also have the option to provide a spinal fluid sample (which requires a special procedure called a lumbar puncture).

AI-generated summary from trial data · Sep 4, 2026 · Not medical advice

Tracking biomarkers and health changes in ALS patients over two years

What is this trial?

Do you qualify?

What participation looks like

Trial locations(37 sites)