Plain-English translation of NCT06578793 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study compares two approaches to treating persistent atrial fibrillation (irregular heartbeat) in people who also have heart failure. One group receives standard catheter ablation—a minimally invasive procedure that uses heat or cold to correct the irregular electrical signals in the heart. The other group receives the same standard procedure plus an additional treatment targeting the Marshall vein using ethanol ablation, which involves injecting a substance into a small vein to reduce abnormal heart rhythm triggers.
Persistent irregular heartbeat combined with heart failure is difficult to treat, and the standard procedure alone doesn't work well enough for many patients. Researchers believe that targeting the Marshall vein may address additional sources of the irregular heartbeat that the standard procedure misses, potentially improving how well the heart pumps and reducing the chance the irregular heartbeat returns.
If you qualify and enroll, you will be randomly assigned to either receive the standard heart rhythm correction procedure alone or the same procedure combined with the Marshall vein treatment. The procedures are performed by a cardiologist using imaging guidance and typically take a few hours. You will need to follow up with the study team to monitor your heart rhythm, heart function, and overall well-being over time to see how well each approach works.
AI-generated summary from trial data · Jul 4, 2026 · Not medical advice
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