Plain-English translation of NCT06579248 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Radiation therapy to the head and neck region commonly damages the sense of taste, which can affect eating, nutrition, and quality of life. This trial is testing an intraoral hypothermia device—a cooling device placed inside the mouth—to see if keeping the mouth and surrounding tissues cool during radiation therapy can preserve or reduce the loss of taste function.
Taste loss is a well-known side effect of head and neck radiation therapy, and there are few proven ways to prevent it. Early research suggests that cooling normal tissues in the mouth during radiation might reduce damage, so this trial is exploring whether this approach could help patients maintain their ability to taste food during cancer treatment.
You likely qualify if…
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You will use the intraoral cooling device during your regular radiation therapy sessions as part of your cancer treatment. The device sits inside your mouth to cool the oral cavity while you receive radiation. You will also fill out questionnaires about your taste, eating ability, and quality of life at various points during and after your treatment to help researchers understand whether the cooling device helps preserve your sense of taste.
AI-generated summary from trial data · Jun 30, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Henry Ford Health System
Enrollment target
~15 participants
Started
November 2024
Primary completion
August 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2026.
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Central contact
Marissa Gilbert, BSBME
Henry Ford Health System
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.