Plain-English translation of NCT06580249 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing repetitive transcranial magnetic stimulation (rTMS)—a non-invasive procedure that uses magnetic pulses to stimulate parts of the brain—combined with sertraline (an antidepressant medication) to treat depression in teenagers ages 10–19. The study focuses specifically on helping teens who have lost the ability to feel pleasure, which is a core symptom of depression. Researchers believe this combination approach may help restore this important emotional capacity.
Depression in teenagers often includes a symptom called anhedonia—the loss of ability to feel pleasure or joy. Current treatments don't always fully address this symptom. This trial exists to see whether combining brain stimulation with medication can more effectively restore the teen's capacity to experience pleasure and improve overall depression symptoms.
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If you join this study, you will receive either real or sham (fake) brain stimulation sessions paired with antidepressant medication. Real rTMS sessions last about 10–20 minutes each and involve magnetic pulses delivered to your scalp; you'll receive one session per day. You'll also take sertraline (or a mood stabilizer if you have bipolar depression) as prescribed. The study team will monitor your symptoms over time to see whether the combination treatment reduces your depression and restores your ability to feel pleasure. You'll need to commit to regular visits and follow the treatment plan closely.
AI-generated summary from trial data · Jul 11, 2026 · Not medical advice
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