A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma — Stella
Phase 2 — Testing in a larger group (up to a few hundred people) to further evaluate safety and begin to assess effectiveness.
(133 sites) United States
Ironwood Cancer & Research Centers, Chandler, Arizona City of Hope National Medical Center, Duarte, California City of Hope National Medical Center, Irvine, California Palo Alto Medical Foundation Research Institute (PAMFRI), Palo Alto, California Stanford Cancer Center, Palo Alto, California Rocky Mountain Cancer Center, Aurora, Colorado University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami, Florida City of Hope National Medical Center, Atlanta Cancer Center, Newnan, Georgia Mission Cancer + Blood, Waukee, Iowa Saint Elizabeth Medical Center Edgewood, Edgewood, Kentucky American Oncology Partners, PA, Bethesda, Maryland Boston Medical Center, Boston, Massachusetts Gulfport Memorial Hospital, Gulfport, Mississippi Comprehensive Cancer Centers of Nevada, Henderson, Nevada East Carolina University, Greenville, North Carolina Williamette Valley Cancer Institute & Research Center, Eugene, Oregon Cancer Care Associates Of York, York, Pennsylvania The West Clinic, PLLC dba West Cancer Center, Germantown, Tennessee USO-Texas Oncology-Central/South Texas, Austin, Texas Sarah Cannon Research Institute/SCRI, The Woodlands, Texas USO-Virginia Oncology Associates, Hampton, Virginia Australia
Flinders Medical Centre, Adelaide Bankstown-Lidcombe Hospital, Bankstown Box Hill Hospital, Box Hill Coffs Harbour Health Campus, Coffs Harbour Royal Hobart Hospital, Hobart ICON Cancer Centre - Kurralta Park, Kurralta Park Latrobe Regional Health, Traralgon Calvary Mater Newcastle, Waratah The Perth Blood Institute - West Perth, West Perth Princess Alexandra Hospital, Woolloongabba Belgium
Institut Jules Bordet, Anderlecht AZ Sint-Jan Brugge-Oostende AV, Bruges Groupe Jolimont, La Louvière Clinique Saint Pierre, Ottignies AZ Nikolaas, Sint-Niklaas CHR Verviers - La Tourelle, Verviers Canada
Royal Victoria Regional Health Centre, Barrie Saskatoon Cancer Centre, Saskatoon Czechia
Fakultní nemocnice Brno Bohunice, Brno Fakultni nemocnice Hradec Kralove, Hradec Králové Fakultni nemocnice Kralovske Vinohrady, Prague Vseobecna fakultni nemocnice v Praze, Prague Denmark
Aarhus Universitetshospital, Skejby, Aarhus Odense Universitetshospital, Odense France
Centre Hospitalier d'Argenteuil Victor Dupouy, Argenteuil Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre, Caen Centre Hospitalier du Mans, Le Mans Groupe Hospitalier de la Région de Mulhouse et Sud Alsace - Hôpital Emile Muller, Mulhouse Centre Antoine-Lacassagne, Nice Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau, Tours Germany
MV-Zentrum für Onkologie und Hämatologie, Cologne Centrum für Hämatologie und Onkologie Bethanien, Frankfurt Onkologisches Ambulanzzentrum Hannover, Hanover Klinikum Aschaffenburg-Alzenau, Hösbach InVO Institut für Versorgungsforschung in der Onkologie, Koblenz Greece
Evangelismos General Hospital of Athens, Athens Attikon General University Hospital, Chaïdári G. Papanikolaou General Hospital, Thessaloniki General Hospital of Athens "Laiko", Αthens Hungary
Semmelweis Egyetem, Budapest Dél-Pesti Centrumkórház, Budapest Pécsi Tudományegyetem Klinikai Központ, Pécs Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ, Szeged Italy
A.O.U.C. Policlinico di Bari, Bari Azienda Ospedaliero Universitaria S.Anna, Cona Azienda Ospedaliera Universitaria Careggi, Florence ASST Grande Ospedale Metropolitano Niguarda, Milan Azienda Ospedaliero Universitaria Maggiore della Carità, Novara Azienda Ospedale - Università Padova, Padova Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO, Palermo AO Santa Maria della Misericordia, Perugia AOU Policlinico Umberto I, Roma Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Roma Poland
Pratia Onkologia Katowice, Katowice Pratia MCM Krakow, Krakow AIDPORT Sp. z o.o., Skórzewo Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Wroclaw Romania
Fundeni Clinical Institute, Bucharest Spitalul Clinic Colțea, Bucharest Institutul Oncologic Cluj, Cluj-Napoca Spitalul Clinic Municipal Filantropia Craiova, Craiova Institutul Regional de Oncologie, Iași Ovidius Clinical Hospital OCH, Ovidiu Slovakia
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica, Banská Bystrica Narodny onkologicky ustav, Bratislava Univerzitna Nemocnica L. Pasteura Kosice, Košice Univerzitna nemocnica Martin, Martin South Korea
Pusan National University Hospital, Busan Chonnam National University Hwasun Hospital, Hwasun-gun Seoul National University Hospital, Seoul Samsung Medical Center, Seoul The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul Spain
Institut Català d'Oncologia (ICO) - Badalona, Badalona Hospital Universitari Vall d'Hebron, Barcelona Hospital Clínic de Barcelona, Barcelona Institut Català d'Oncologia - L'Hospitalet, L'Hospitalet Del Llobregat Clinica Universidad de Navarra, Madrid Hospital Universitario Infanta Leonor, Madrid MD Anderson Cancer Center, Madrid Hospital Universitario Ramón y Cajal, Madrid Hospital Universitario Quironsalud Madrid, Madrid Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda Hospital Costa del Sol, Marbella Hospital Universitario Central de Asturias, Oviedo Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca
Turkey (Türkiye)
Sakarya University School of Medicine, Adapazarı Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi, Ankara Ankara University Health Practice and Research Hospitals, Ankara Memorial Antalya Hospital, Antalya Yeditepe Üniversitesi Koşuyolu Hastanesi, Istanbul Ege Universitesi Hastanesi, Izmir Kocaeli Üniversitesi, İzmit VM Medical Park Mersin Hastanesi, Mersin Ondokuz Mayıs Universitesi, Samsun United Kingdom
Heartlands Hospital, Birmingham The Beatson West of Scotland Cancer Centre, Glasgow Northwick Park Hospital, Harrow St James's University Hospital, Leeds Lincoln County Hospital, Lincoln Clatterbridge Cancer Centre - Liverpool, Liverpool Hammersmith Hospital, London Maidstone Hospital, Maidstone Singleton Hospital, Swansea
Key details Sponsor
Loxo Oncology, Inc.
Collaborators
Eli Lilly and Company
Enrollment target
~249 participants
Primary completion
June 2028
Hospital Universitario Marqués de Valdecilla, Santander
Hospital Universitario Virgen Macarena, Seville Hospital Universitario Virgen Del Rocio, Seville