Plain-English translation of NCT06589440 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This is a Phase 2 trial testing (taken by mouth) combined with two intravenous medications called botensilimab and balstilimab for people with advanced colorectal cancer that has spread to other parts of the body. The study will look at whether this medication combination is safe and whether it helps slow or stop the cancer's growth. Researchers will also compare how well the treatment works in patients whose cancer has spread to the liver versus those without liver involvement.
Colorectal cancer that hasn't responded to standard chemotherapy treatments is very difficult to manage, and patients with this type urgently need new options. This trial is testing whether this medication can boost the body's immune system to fight this type of cancer more effectively.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will take an oral medication by mouth daily while also receiving intravenous (IV) infusions of the other two drugs at the study clinic. You will have regular clinic visits for blood tests, imaging scans, and check-ups to monitor how the treatment is working and any side effects. The study will track your health carefully throughout the treatment period and involves providing a sample of your tumor tissue so researchers can better understand how the medication works.
AI-generated summary from trial data · Aug 18, 2026 · Not medical advice
United States