Plain-English translation of NCT06591091 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing whether clemastine, an antihistamine medication commonly used for allergies, might help repair brain tissue and make antidepressant medications work better in older adults with depression. Researchers believe that improving the brain's white matter—the tissue that helps different brain regions communicate—could reduce depression symptoms and improve memory and thinking. You would take this medication along with a standard antidepressant for 12 weeks.
Late-life depression is often difficult to treat and can affect memory and thinking. Some research suggests that problems with brain tissue called white matter make depression harder to treat in older adults, and this medication might help repair that tissue.
You likely qualify if…
You likely don't qualify if…
You would be in the study for 12 weeks and randomly assigned to receive either the medication being tested plus a standard antidepressant, or a placebo plus a standard antidepressant. During the study, you'll have visits where researchers assess your mood, memory, and thinking, and take special brain images to see if the medication helps repair brain tissue. You may also be taking other medications for sleep or anxiety as needed, and can continue therapy if you're already doing it.
AI-generated summary from trial data · Jul 19, 2026 · Not medical advice
United States