Plain-English translation of NCT06592261 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This is a basic science study designed to understand a puzzle about insulin and weight. Researchers want to figure out whether high insulin levels actually cause insulin resistance in people with obesity, or whether the body produces extra insulin simply as a response to insulin resistance. To answer this question, the study uses a specialized test that carefully measures how your body handles insulin at different levels.
Many people with obesity have both high insulin levels and insulin resistance, which puts them at risk for type 2 diabetes. However, scientists aren't sure which comes first — does the high insulin cause the insulin resistance, or is the high insulin just the body's attempt to compensate? Understanding this relationship could lead to better ways to prevent and treat type 2 diabetes.
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You will come to Columbia University Medical Center for a single outpatient visit lasting several hours. During the visit, researchers will place a small catheter (tube) in your vein and give you medication to suppress your natural insulin production. Then they will carefully infuse insulin and glucose (sugar) intravenously at two different levels — first at a lower level and then at a higher level — while frequently checking your blood sugar every 5–15 minutes. Throughout the test, your blood pressure and heart rate will be monitored.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
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